When he came to Ecbatana in Media, and had despatched his most urgent affairs, he began to divert himself again with spectacles and public entertainments, to carry on which he had a supply of three thousand actors and artists, newly arrived out of Greece. But they were soon interrupted by Hephaestion's falling sick of a fever, in which, being a young man and a soldier, too, he could not confine himself to so exact a diet as was necessary; for whilst his physician, Glaucus, was gone to the theatre, he ate a fowl for his dinner, and drank a large draught of wine, upon which he became very ill, and shortly after died. At this misfortune, Alexander was so beyond. all reason transported that, to express his sorrow, he immediately ordered the manes and tails of all his horses and mules to be cut, and threw down the battlements of the neighbouring cities. The poor physician he crucified, and forbade playing on the flute or any other musical instrument in the camp a great while, till directions came from the oracle of Ammon, and enjoined him to honour Hephaestion, and sacrifice to him as a hero. Then seeking to alleviate his grief in war, he set out, as it were, to a hunt and chase of men, for he fell upon the Cossaeans, and put the whole nation to the sword. This was called a sacrifice to Hephaestion's ghost. In his sepulchre and monument and the adorning of them he intended to bestow ten thousand talents; and designing that the excellence of the workmanship and the singularity of the design might outdo the expense, his wishes turned, above all other artists, to Stasicrates, because he always promised something very bold, unusual, and magnificent in his projects. Once when they had met before, he had told him that, of all the mountains he knew, that of Athos in Thrace was the most capable of being adapted to represent the shape and lineaments of a man; that if he pleased to command him, he would make it the noblest and most durable statue in the world, which in its left hand should hold a city of ten thousand inhabitants, and out of its right should pour a copious river into the sea. Though Alexander declined this proposal, yet now he spent a great deal of time with workmen to invent and contrive others even more extravagant and sumptuous.
As he was upon his way to Babylon, Nearchus, who had sailed back out of the ocean up the mouth of the river Euphrates, came to tell him he had met with some Chaldaean diviners, who had warned him against Alexander's going thither. Alexander, however, took no thought of it, and went on, and when he came near the walls of the place, he saw a great many crows fighting with one another, some of whom fell down just by him. After this, being privately informed that Apollodorus, the governor of Babylon, had sacrificed, to know what would become of him, he sent for Pythagoras, the soothsayer, and on his admitting the thing, asked him in what condition he found the victim; and when he told him the liver was defective in its lobe, "Agreat presage indeed!" said Alexander. However, he offered Pythagoras no injury, but was sorry that he had neglected Nearchus's advice, and stayed for the most part outside the town, removing his tent from place to place, and sailing up and down the Euphrates.
Besides this, he was disturbed by many other prodigies. A tame ass fell upon the biggest and handsomest lion that he kept, and killed him by a kick. And one day after he had undressed himself to be anointed, and was playing at ball, just as they were going to bring his clothes again, the young men who played with him perceived a man clad in the king's robes with a diadem upon his head, sitting silently upon his throne. They asked him who he was, to which he gave no answer a good while, till at last, coming to himself, he told them his name was Dionysius that he was of Messenia, that for some crime of which he was accused he was brought thither from the seaside, and had been kept long in prison, that Serapis appeared to him, had freed him from his chains, conducted him to that place, and commanded him to that place, and commanded him to put on the king's robe and diadem, and to sit where they found him, and to say nothing. Alexander, when he heard this, by the direction of his soothsayers, put the fellow to death, but he lost his spirits, and grew diffident of the protection and assistance of the gods, and suspicious of his friends. His greatest apprehension was of Antipater and his sons, one of whom, Iolaus, was his chief cupbearer; and Cassander, who had lately arrived, and had been bred up in Greek manners, the first time he saw some of the barbarians adore the king could not forbear laughing at it aloud, which so incensed Alexander he took him by the hair with both hands and dashed his head against the wall. Another time, Cassander would have said something in defence of Antipater to those who accused him, but Alexander interrupting him, said, "What is it you say? Do you think people, if they had received no injury, would come such a journey only to calumniate your father?" To which when Cassander replied, that their coming so far from the evidence was a great proof of the falseness of their charges, Alexander smiled, and said those were some of Aristotle's sophisms, which would serve equally on both sides; and added, that both he and his father should be severely punished, if they were found guilty of the least injustice towards those who complained. All which made such a deep impression of terror in Cassander's mind that, long after, when he was King of Macedonia and master of Greece, as he was walking up and down at Delphi, and looking at the statues, at the sight of that of Alexander he was suddenly struck with alarm, and shook all over, his eyes rolled, his head grew dizzy, and it was long before he recovered himself.